Vaccination is the most successful and universally applied strategy for prevention of some childhood infectious diseases. However, many parents refuse to vaccinate their children due to concerns over safety and utility of vaccines. This threatens the risk of an increase in the vaccine-preventable diseases which are associated with significant mortality and morbidity. This research aims to identify causes of refusal or hesitancy to vaccination of children by parents so that implications can be made as what is the best clinician approach towards parents who refuse to vaccinate their children. The articles were retrieved from PUB MED after typing the terms refusal for vaccination. The inclusion criteria were articles after 2004 and those displayed in English. Only quality and peer-reviewed articles were taken into consideration. Several articles were displayed and the following articles were selected after scanning through the abstracts of the articles. Parents who refuse to vaccinate their children consciously are stubborn and need to be handled with sensitivity to convince them about the benefits of vaccination. In a study by Gullion and Henry (2008), the researchers explored various attitudes and beliefs of parents who chose not to vaccinate their child consciously/ The study was a semistructured interview and from the data, thematic analysis was done through which 2 themes were identified: 1) A desire to collect information on vaccines. 2) Trust issues with the medical community. According to the researchers, it is very important to understand the differences between the knowledge of an expert and knowledge of a lay person to craft appropriate health messages. This is because the decision-making process of this group is strongly influenced by the framing of knowledge by experts. Asking parents to do something just because the message came from a doctor, no longer works in this group of people who view themselves in partnership with experts and see themselves as bringers of legitimate findings of the safety of vaccines.